PRF (Platelet Rich Fibrin)

Introducing the next generation blood concentrate, PRF (Platelet Rich Fibrin).

Using our own cells has become a mainstream form of regeneration and rejuvenation. While PRP (platelet rich plasma) is a very popular blood concentrate for wound healing and rejuvenation, there now is a more advanced, fully autologous form of blood concentrate called PRF (Platelet Rich Fibrin).

What is the difference between PRP and PRF?

Simply, PRF amplifies the regenerative powers of PRP.

PRF has a 10x higher concentration of platelets and a more robust release of growth factors than PRP. PRF includes a dense fibrin matrix which extends the cycles of tissue repair and cell regeneration. This fibrin matrix keeps cells active and alive for over a week. With traditional PRP, growth factors can stay active for only a few minutes to a few hours.

The extended life of active cells is important for continued regeneration. The fibrin matrix of PRF allows for a steady, durable release of growth factors.

The fibrin matrix of PRF can form because PRF is fully autologous; there are no anti-coagulants involved in the process. Translation: PRF is a 100% natural, unmodified solution.

Conversely, a fibrin matrix cannot form with PRP. The PRP process uses anti-coagulants.

The process makes the difference.

PRP’s high speed centrifugation is to eliminate red blood cells by pushing them down with gravitational force. It has been shown that spinning blood too fast and too long results in pushing down heavier cells such as white blood cells and stem cells, while “lighter” platelets and plasma collect at the top of the tube. This top part, or lighter cells, is what PRP uses for regeneration and rejuvenation.

PRF’s slow speed centrifugation preserves the vitality of cells that remain undamaged because of the low G-force applied. With slow speed centrifugation of PRF, a considerable amount of white blood cells (WBCs) and mesenchymal stem cells (MSCs) also are obtained. Mesenchymal stem cells are highly desirable as these multipotent stem cells can differentiate into other cell types.

With the high concentration of platelets, approximately 10x more than normal blood, white blood cells and fibrin, PRF has superior regenerative and healing capabilities in comparison to PRP.

PRF is “The Ultimate Blood Concentrate.”

Benefits of PRF

• 100% Natural
• Contains fibrin
• Growth factors harvested with PRF stay active and alive for a little over a week
• PRF also can be converted to a gel form and used as a bio-stimulating and volumizing dermal filler.
• While lifespan and space filling capabilities as a “dermal filler” is unpredictable and varies between patients, PRF is the ultimate booster for traditional fillers and Sculptra
• PRF is the safest injectable for one of the most troublesome, high-risk areas for patients – the tear troughs

Common Uses for PRF in Aesthetic Medicine

• Boost results and longevity of hyaluronic acid fillers (Restylane, Juvéderm)
• Boost results of Sculptra injections
• Boost results of RF microneedling and lasers

• Boost results of hair restoration
• Tear trough restoration and rejuvenation
• Used in place of tradition fillers for volume loss, enhancement, atrophic scar therapy, general skin rejuvenation
• Increase success rate of vaginal rejuvenation procedures